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Open-weight model

reproduce_deepsea

by Wuzheng Dong aer0vane/reproduce_deepsea

reproduce_deepsea is a model from Wuzheng Dong (access requested at publisher). Its published files total 36.5 GB.

Model weights, prediction arrays, and experiment data for the DeepSEA reproduction project. The GitHub repository provides experiment code, plotting scripts, figures, and data guides.

Parameters—
Context—
Weights2.0 GB
License—
AccessAccess requested at publisher
Monthly Downloads—

Model Card

Model weights, prediction arrays, and experiment data for the DeepSEA reproduction project. The GitHub repository provides experiment code, plotting scripts, figures, and data guides. - Our final trained model, epoch 53: trainingcheckpoints/bestmodelFINALEPOCH53.pth. The root file predictornames.txt provides shared DeepSEA output feature names. For other experiments, replace the include pattern with the corresponding experiment/ / path. Shared source data, inference instructions, and reference genome sources are documented in the GitHub download guide. Academic and commercial use is prohibited through 30 November 2026. Beginning 1 December 2026, this project will be released under the MIT…

Excerpt from the card by Wuzheng Dong.

Identity and Version

Repository
aer0vane/reproduce_deepsea
Publisher
Wuzheng Dong
Task
Not stated by the source
Modality
Other
Library
Not stated by the source
Parameters
Not stated by the source
Languages
Not stated by the source
Revision
202ba7262675b3e5da91501332c513385f9e394e
First published
2026-10-05
Last updated
2026-10-10

Files and Weights

214 files, 36.5 GB in total. The weights are 108 files totalling 2.0 GB in npz, pth.

Weights108 files · 2.0 GB
Configuration20 files · 40.7 KB
Documentation11 files · 10.6 KB
Other74 files · 34.6 GB
Repository1 file · 2.6 KB
Every file
FileTypeSizeSHA-256
experiment/Supplementary_Figure2/results/test_indices.npzWeights8.8 MB —
experiment/Supplementary_Figure3/results/experiment6_all_data.npzWeights88.2 MB —
experiment/Supplementary_Figure3/results/experiment6_raw_predictions.npzWeights81.7 MB —
experiment/Supplementary_Figure4/results/histone_qtl_raw_predictions.npzWeights38.2 MB —
experiment/Supplementary_Figure7/results/eqtl_conservation_fold00.npzWeights567.5 KB —
experiment/Supplementary_Figure7/results/eqtl_conservation_fold01.npzWeights566.8 KB —
experiment/Supplementary_Figure7/results/eqtl_conservation_fold02.npzWeights555.5 KB —
experiment/Supplementary_Figure7/results/eqtl_conservation_fold03.npzWeights581.5 KB —
experiment/Supplementary_Figure7/results/eqtl_conservation_fold04.npzWeights562.5 KB —
experiment/Supplementary_Figure7/results/eqtl_conservation_fold05.npzWeights574.5 KB —
experiment/Supplementary_Figure7/results/eqtl_conservation_fold06.npzWeights539.4 KB —
experiment/Supplementary_Figure7/results/eqtl_conservation_fold07.npzWeights568.3 KB —
experiment/Supplementary_Figure7/results/eqtl_conservation_fold08.npzWeights558.9 KB —
experiment/Supplementary_Figure7/results/eqtl_conservation_fold09.npzWeights538.6 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_chromatin_fold00.npzWeights572.5 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_chromatin_fold01.npzWeights573.4 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_chromatin_fold02.npzWeights559.9 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_chromatin_fold03.npzWeights585.9 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_chromatin_fold04.npzWeights571.8 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_chromatin_fold05.npzWeights578.6 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_chromatin_fold06.npzWeights545.4 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_chromatin_fold07.npzWeights574.5 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_chromatin_fold08.npzWeights564.4 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_chromatin_fold09.npzWeights547.5 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_combined_fold00.npzWeights580.3 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_combined_fold01.npzWeights581.0 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_combined_fold02.npzWeights568.0 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_combined_fold03.npzWeights592.9 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_combined_fold04.npzWeights578.5 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_combined_fold05.npzWeights586.6 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_combined_fold06.npzWeights553.9 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_combined_fold07.npzWeights582.8 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_combined_fold08.npzWeights572.2 KB —
experiment/Supplementary_Figure7/results/eqtl_ours_combined_fold09.npzWeights554.9 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_chromatin_fold00.npzWeights577.4 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_chromatin_fold01.npzWeights578.3 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_chromatin_fold02.npzWeights565.2 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_chromatin_fold03.npzWeights590.5 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_chromatin_fold04.npzWeights576.8 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_chromatin_fold05.npzWeights583.8 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_chromatin_fold06.npzWeights550.6 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_chromatin_fold07.npzWeights579.7 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_chromatin_fold08.npzWeights569.5 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_chromatin_fold09.npzWeights552.5 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_combined_fold00.npzWeights581.1 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_combined_fold01.npzWeights581.8 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_combined_fold02.npzWeights568.8 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_combined_fold03.npzWeights593.6 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_combined_fold04.npzWeights579.5 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_combined_fold05.npzWeights587.5 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_combined_fold06.npzWeights554.5 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_combined_fold07.npzWeights583.7 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_combined_fold08.npzWeights573.0 KB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_combined_fold09.npzWeights555.9 KB —
experiment/Supplementary_Figure7/results/gwas_conservation_fold00.npzWeights495.5 KB —
experiment/Supplementary_Figure7/results/gwas_conservation_fold01.npzWeights489.4 KB —
experiment/Supplementary_Figure7/results/gwas_conservation_fold02.npzWeights494.0 KB —
experiment/Supplementary_Figure7/results/gwas_conservation_fold03.npzWeights497.6 KB —
experiment/Supplementary_Figure7/results/gwas_conservation_fold04.npzWeights487.7 KB —
experiment/Supplementary_Figure7/results/gwas_conservation_fold05.npzWeights496.8 KB —
experiment/Supplementary_Figure7/results/gwas_conservation_fold06.npzWeights488.1 KB —
experiment/Supplementary_Figure7/results/gwas_conservation_fold07.npzWeights492.6 KB —
experiment/Supplementary_Figure7/results/gwas_conservation_fold08.npzWeights489.6 KB —
experiment/Supplementary_Figure7/results/gwas_conservation_fold09.npzWeights478.5 KB —
experiment/Supplementary_Figure7/results/gwas_ours_chromatin_fold00.npzWeights500.5 KB —
experiment/Supplementary_Figure7/results/gwas_ours_chromatin_fold01.npzWeights495.4 KB —
experiment/Supplementary_Figure7/results/gwas_ours_chromatin_fold02.npzWeights497.3 KB —
experiment/Supplementary_Figure7/results/gwas_ours_chromatin_fold03.npzWeights500.9 KB —
experiment/Supplementary_Figure7/results/gwas_ours_chromatin_fold04.npzWeights495.6 KB —
experiment/Supplementary_Figure7/results/gwas_ours_chromatin_fold05.npzWeights500.0 KB —
experiment/Supplementary_Figure7/results/gwas_ours_chromatin_fold06.npzWeights492.6 KB —
experiment/Supplementary_Figure7/results/gwas_ours_chromatin_fold07.npzWeights497.8 KB —
experiment/Supplementary_Figure7/results/gwas_ours_chromatin_fold08.npzWeights494.4 KB —
experiment/Supplementary_Figure7/results/gwas_ours_chromatin_fold09.npzWeights486.2 KB —
experiment/Supplementary_Figure7/results/gwas_ours_combined_fold00.npzWeights507.3 KB —
experiment/Supplementary_Figure7/results/gwas_ours_combined_fold01.npzWeights502.4 KB —
experiment/Supplementary_Figure7/results/gwas_ours_combined_fold02.npzWeights504.8 KB —
experiment/Supplementary_Figure7/results/gwas_ours_combined_fold03.npzWeights507.8 KB —
experiment/Supplementary_Figure7/results/gwas_ours_combined_fold04.npzWeights501.7 KB —
experiment/Supplementary_Figure7/results/gwas_ours_combined_fold05.npzWeights507.4 KB —
experiment/Supplementary_Figure7/results/gwas_ours_combined_fold06.npzWeights501.1 KB —
experiment/Supplementary_Figure7/results/gwas_ours_combined_fold07.npzWeights505.9 KB —
experiment/Supplementary_Figure7/results/gwas_ours_combined_fold08.npzWeights501.5 KB —
experiment/Supplementary_Figure7/results/gwas_ours_combined_fold09.npzWeights493.6 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_chromatin_fold00.npzWeights503.9 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_chromatin_fold01.npzWeights499.3 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_chromatin_fold02.npzWeights501.4 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_chromatin_fold03.npzWeights504.8 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_chromatin_fold04.npzWeights499.6 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_chromatin_fold05.npzWeights504.0 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_chromatin_fold06.npzWeights497.1 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_chromatin_fold07.npzWeights502.1 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_chromatin_fold08.npzWeights498.3 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_chromatin_fold09.npzWeights490.3 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_combined_fold00.npzWeights507.5 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_combined_fold01.npzWeights502.6 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_combined_fold02.npzWeights505.1 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_combined_fold03.npzWeights508.2 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_combined_fold04.npzWeights502.2 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_combined_fold05.npzWeights507.9 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_combined_fold06.npzWeights501.3 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_combined_fold07.npzWeights506.2 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_combined_fold08.npzWeights502.0 KB —
experiment/Supplementary_Figure7/results/gwas_pretrained_combined_fold09.npzWeights494.0 KB —
models/deepsea_predict.pthWeights211.4 MB —
training_checkpoints/archive/best_model_epoch21.pthWeights211.4 MB —
training_checkpoints/archive/checkpoint_epoch46_adam_auc0915.pthWeights634.1 MB —
training_checkpoints/best_model_FINAL_EPOCH53.pthWeights634.1 MB —
experiment/Figure2/input_manifest.jsonConfiguration3.3 KB —
experiment/Figure3/outputs/baseline_source_manifest.jsonConfiguration2.7 KB —
experiment/Figure3/outputs/eqtl_ours_summary.jsonConfiguration1.0 KB —
experiment/Figure3/outputs/eqtl_pretrained_summary.jsonConfiguration1.1 KB —
experiment/Figure3/outputs/eqtl_verification.jsonConfiguration350 B —
experiment/Figure3/outputs/feature_verification.jsonConfiguration467 B —
experiment/Figure3/outputs/gwas_ours_summary.jsonConfiguration1.0 KB —
experiment/Figure3/outputs/gwas_pretrained_summary.jsonConfiguration1.1 KB —
experiment/Figure3/outputs/gwas_verification.jsonConfiguration350 B —
experiment/Figure3/outputs/manifest.jsonConfiguration3.2 KB —
experiment/Figure3/outputs/metrics_provenance.jsonConfiguration5.2 KB —
experiment/Figure3/outputs/prepared.jsonConfiguration108 B —
experiment/Figure3/outputs/publisher_source_verification.jsonConfiguration1.4 KB —
experiment/Figure3/outputs/run_environment_checks.jsonConfiguration1.0 KB —
experiment/Figure3/outputs/source_cohort_checks.jsonConfiguration816 B —
experiment/Supplementary_Figure2/results/run_metadata.jsonConfiguration488 B —
experiment/Supplementary_Figure3/results/experiment6_plot_metadata.jsonConfiguration1.0 KB —
experiment/Supplementary_Figure7/results/run_manifest.jsonConfiguration2.3 KB —
taskB/metrics/funseq2_manifest.jsonConfiguration1.7 KB —
taskB/metrics/nt50m_run_manifest.jsonConfiguration12.0 KB —
README.mdDocumentation4.1 KB —
experiment/Figure2/README.mdDocumentation539 B —
experiment/Figure3/README.mdDocumentation493 B —
experiment/Supplementary_Figure1/README.mdDocumentation385 B —
experiment/Supplementary_Figure2/README.mdDocumentation816 B —
experiment/Supplementary_Figure3/README.mdDocumentation367 B —
experiment/Supplementary_Figure4/README.mdDocumentation620 B —
experiment/Supplementary_Figure6/README.mdDocumentation2.1 KB —
experiment/Supplementary_Figure7/README.mdDocumentation468 B —
experiment/experiment7_rerun/README.mdDocumentation345 B —
taskB/README.mdDocumentation376 B —
experiment/Figure2/outputs/dgf_alt_preds_ours.npyOther114.0 MB —
experiment/Figure2/outputs/dgf_alt_preds_pretrained.npyOther114.0 MB —
experiment/Figure2/outputs/dgf_ref_preds_ours.npyOther114.0 MB —
experiment/Figure2/outputs/dgf_ref_preds_pretrained.npyOther114.0 MB —
experiment/Figure2/outputs/test_labels.npyOther418.2 MB —
experiment/Figure2/outputs/test_predictions_ours.npyOther1.7 GB —
experiment/Figure2/outputs/test_predictions_pretrained.npyOther1.7 GB —
experiment/Figure3/outputs/auc_summary.csvOther1.7 KB —
experiment/Figure3/outputs/eqtl_CADD_scores.tsv.gzOther19.0 MB —
experiment/Figure3/outputs/eqtl_ours_oof.tsv.gzOther24.7 MB —
experiment/Figure3/outputs/eqtl_pretrained_oof.tsv.gzOther24.8 MB —
experiment/Figure3/outputs/funseq2_v2.1.0_scores.tsv.gzOther2.9 MB —
experiment/Figure3/outputs/gwas_CADD_scores.tsv.gzOther16.9 MB —
experiment/Figure3/outputs/gwas_ours_oof.tsv.gzOther22.0 MB —
experiment/Figure3/outputs/gwas_pretrained_oof.tsv.gzOther22.0 MB —
experiment/Figure3/outputs/gwava_GRCh37_scores.tsv.gzOther2.6 MB —
experiment/Figure3/outputs/ours_effects.npyOther13.6 GB —
experiment/Figure3/outputs/pretrained_effects.npyOther13.6 GB —
experiment/Figure3/outputs/pretrained_ours_baselines_auc.csvOther7.3 KB —
experiment/Figure3/outputs/variants.tsvOther59.4 MB —
experiment/Supplementary_Figure2/feature_models_and_indices.tar.zstOther927.1 MB —
experiment/Supplementary_Figure2/results/deepsea_inference_test_indices.npyOther909.8 KB —
experiment/Supplementary_Figure2/results/ours_same_test_predictions.npyOther626.8 MB —
experiment/Supplementary_Figure2/results/pretrained_same_test_predictions_agct.npyOther626.8 MB —
experiment/Supplementary_Figure3/sequences/snp_chr10_23508363.npyOther16.1 KB —
experiment/Supplementary_Figure3/sequences/snp_chr16_209709.npyOther16.1 KB —
experiment/Supplementary_Figure3/sequences/snp_chr16_52599188.npyOther16.1 KB —
experiment/Supplementary_Figure3/sequences/snp_chr1_109817590.npyOther16.1 KB —
experiment/Supplementary_Figure4/results/ours_variant_predictions.tsvOther721.0 KB —
experiment/Supplementary_Figure4/results/pretrained_variant_predictions.tsvOther721.8 KB —
experiment/Supplementary_Figure6/inputs/eqtl_gwas_variants_for_cadd_inclAnno.vcf.gzOther9.1 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_01.tsv.gzOther8.5 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_02.tsv.gzOther8.5 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_03.tsv.gzOther7.7 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_04.tsv.gzOther7.5 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_05.tsv.gzOther7.4 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_06.tsv.gzOther7.7 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_07.tsv.gzOther7.9 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_08.tsv.gzOther7.6 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_09.tsv.gzOther7.6 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_10.tsv.gzOther7.3 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_11.tsv.gzOther7.4 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_12.tsv.gzOther7.4 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_13.tsv.gzOther7.4 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_14.tsv.gzOther7.7 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_15.tsv.gzOther8.1 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_16.tsv.gzOther7.6 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_17.tsv.gzOther7.5 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_18.tsv.gzOther8.0 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_19.tsv.gzOther7.7 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_20.tsv.gzOther7.8 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_21.tsv.gzOther7.3 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_22.tsv.gzOther7.5 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_23.tsv.gzOther7.5 MB —
experiment/Supplementary_Figure6/outputs/cadd_inclAnno_batch_24.tsv.gzOther8.9 MB —
experiment/Supplementary_Figure6/outputs/eqtl_unsupervised_ours.tsv.gzOther82.8 MB —
experiment/Supplementary_Figure6/outputs/eqtl_unsupervised_pretrained.tsv.gzOther83.1 MB —
experiment/Supplementary_Figure6/outputs/gwas_unsupervised_ours.tsv.gzOther72.5 MB —
experiment/Supplementary_Figure6/outputs/gwas_unsupervised_pretrained.tsv.gzOther72.8 MB —
experiment/Supplementary_Figure7/results/auc_by_group.csvOther5.6 KB —
experiment/Supplementary_Figure7/results/eqtl_conservation_oof.tsv.gzOther18.6 MB —
experiment/Supplementary_Figure7/results/eqtl_ours_chromatin_oof.tsv.gzOther18.7 MB —
experiment/Supplementary_Figure7/results/eqtl_ours_combined_oof.tsv.gzOther18.9 MB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_chromatin_oof.tsv.gzOther18.8 MB —
experiment/Supplementary_Figure7/results/eqtl_pretrained_combined_oof.tsv.gzOther18.9 MB —
experiment/Supplementary_Figure7/results/gwas_conservation_oof.tsv.gzOther16.7 MB —
experiment/Supplementary_Figure7/results/gwas_ours_chromatin_oof.tsv.gzOther16.7 MB —
experiment/Supplementary_Figure7/results/gwas_ours_combined_oof.tsv.gzOther16.9 MB —
experiment/Supplementary_Figure7/results/gwas_pretrained_chromatin_oof.tsv.gzOther16.8 MB —
experiment/Supplementary_Figure7/results/gwas_pretrained_combined_oof.tsv.gzOther16.9 MB —
predictor_names.txtOther17.3 KB —
taskB/metrics/funseq2_coverage.tsvOther536 B —
taskB/metrics/method_metrics.tsvOther1.6 KB —
taskB/predictions/clinvar_available_method_scores.tsv.gzOther501.6 KB —
.gitattributesRepository2.6 KB —

License and Download

License
Not stated by the source
Access
Access requested at publisher
Download size
2.0 GB
Request access from Wuzheng Dong

Wuzheng Dong grants access through its official repository on Hugging Face.

Memory Requirements

PrecisionWeights in memory
As published2.0 GB

Weights only, from the published parameter count; the key-value cache and runtime add to this.